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Model building The maximal effect (E max ) model built up via non-linear mixed-effect modeling (NONMEM, edition 7, ICON Development Solutions, Ellicott City, MD, United States) was used for analysis

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The pathogenesis of sarcopenia is complex and multifaceted: the chronic catabolic condition, increased energy expenditure, reduced appetite, side effects of multiple therapies, alterations in circulating levels of hormones, low protein synthesis, and the presence of ascites or portosystemic shunts are all factors contributing to muscle atrophy in cirrhotic patients [23]

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Tambin ha sido aprobada por la Administracin de Alimentos y Medicamentos de los Estados Unidos (FDA) como un medicamento para tratar los sntomas de deficiencia primaria y ciertos sntomas secundarios de carnitina

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