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Description

Identification of a functional antioxidant response element at the HIF1A locus

doi: 10.1038/s41579-023-00861-x 120 BlackwellM

Dihydroartemisinin (DHA) exemplifies this duality: at low concentrations or under specific conditions, DHA can paradoxically increase GPX4 activity by upregulating ATF4 expression, potentially suppressing ferroptosis