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J Pharmacol Exp Ther 354:269278

10.1016/j.jtemb.2014.06.017 J Trace Elem Med Biol

By providing bilevel positive airway pressure (BiPAP), NIV effectively counteracts intrinsic PEEP, improves ventilation/perfusion (V/Q) matching, and thus alleviates respiratory muscle fatigue (Sehgal et al., 2019)

Thus, dynamic variation in alveolar p O 2 and its effect on cellular redox state may impose a direct role in modulating the pattern of gene expression and, thus, could be crucial in determining cellular fate and the inflammatory process regulated by cytokines [3646, 166, 164]