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It should begin with a diagnosis and a mechanistic gap

[DOI] [PMC free article] [PubMed] [Google Scholar] Fu M, Zhang W, Wu L, Yang G, Li H, Wang R (2012)

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This is why the combination of a GHRH analog with a GHSR agonist has become one of the most widely used protocols in clinical practice: two independent signals converging on the same outcome, producing a synergistic GH response that exceeds what either pathway achieves alone.