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Our study has several important limitations

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Because of the dual biochemical origin of elevated Hcy, this biomarker is of limited value to assess vitamin B 12 status as a stand-alone measurement

Glucosylceramide synthase inhibitors have been shown to reduce the levels of glucosylceramide and glucosylsphingosine in the central nervous system, decelerate the accumulation of -syn, ubiquitin and tau proteins and improve cognitive and behavioral outcome in a GBA-associated PD mouse model (Sardi et al

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