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Galactose modified prodrugs Duocarmycin Senescent cells are characterized by high levels of (SA--Galactosidase) implying that generation of prodrugs combining a cytotoxic compound linked to a cleavable galactose part should be preferentially processed by those cells

Recently, a hybrid model (cuprizone autoimmune encephalitis or CAE) combining the myelin-toxic effects of cuprizone (Zirngibl et al., 2022) together with an immune stimulation identical to EAE but without extrinsic myelin peptides, provided proof-of-principle for the notion that a primary biochemical dysmyelination can result in a very typical inflammatory demyelinating white matter lesion in an immune-stimulated host (Caprariello et al., 2018)

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Zinc), anti-inflammatory and antiaggregating properties (Reddy et al

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