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To isolate the metabolic effects of the transcriptional status of HIV1, we focused on the role of the lentiviral transactivator Tat protein, which is required for the expression of the integrated provirus through binding to the transactivation response (TAR) region, but can also activate numerous cellular genes and molecular networks, especially those involved in inflammatory responses (Clark et al , 2017)

The mechanism and timeline are the same as for male patients, with some adjustments in the protocol for patients in perimenopause or menopause where hormonal changes affect collagen synthesis and healing rates

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[0319] As indicated above, in various embodiments, the antibody binds (e.g., specifically binds ALPP and/or ALPPL2 (see, e.g., Fig 1 for ALPP and ALPPL2 sequences)

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