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Recently, we demonstrated that the cyclolignan PPP inhibited phosphorylation of IGF-1R without interfering with insulin receptor activity (Girnita et al, 2004), as well as it reduced phosphorylated Akt, caused apoptosis and induced tumour regression in xenografted mice

Baruch, K

Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells

In this system, under dark conditions, phosphorylated FixJ protein was transferred from YF1 protein to FixJ protein, and phosphorylated FixJ protein activated pFIXK2 promoter, then activated downstream gene expression

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In summary, selective inhibition targeting GPIb and Mac-1 may be an effective therapeutic approach to attenuate thrombotic inflammatory diseases