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Elevated AIM levels are observed in both SLE patients (343) and lupus prone mice (344), correlating with SLE disease activity (343)

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By checking the meRIP-seq data to determine whether the m6A modification was enriched in the SLC7A11 sequence, we found that SLC7A11 clearly showed m6A level downregulation by comparing the difference in m6A peak on the SLC7A11 INPUT and IP samples ( Figure 5C )

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The median (Q1, Q3) qFibrosis value was 1.70 (1.39, 2.38) with a range from 0.48 7.77

Curcumin blocks cytokine-mediated Nf-b activation and Proinflammatory gene expression by inhibiting inhibitory factor I-b kinase activity