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Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE (2004) Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

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Exposure of astrocytes to extracellular L-lactate and selective HCA1 agonists, 3Cl-5OH-BA 626 or Compound 2 627 , triggers responses similar to those mediated by -adrenoceptors 628,629,630 , namely an increase in cAMP, cAMP-dependent PKA activity and L-lactate production