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While intramuscular bioavailability is reported at 14-19% in rodent models and 45-51% in canine models, oral bioavailability demonstrates lower but measurable systemic exposure

The flavonoid isoliquiritigenin (ISL) triggers mitochondria-dependent apoptosis by disrupting the balance between the protective Nrf2-HO-1 and the stress-related JNK/ERK pathways (Song et al., 2020)