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Priority should also be given to studies that apply standardised outcome measures, including UPDRS with MCID reporting, DAT imaging, and validated oxidative stress biomarkers

4E, F) in the presence of LiCl

These protocols are often based on antioxidant therapies such as glutathione combined with vitamin C and other supportive nutrients

Future research is warranted to further explore advanced resistance training techniques, as these approaches may offer comparable benefits for physical and mental health to those seen with other forms of exercise such as high-intensity interval training and heavy resistance training

It has been demonstrated that ebselen possesses otoprotective activity and alleviated NIHL in rat via preventing the loss of outer HCs and reduces the acute swelling of the stria vascularis (Kil et al., 2007), it can also attenuate cisplatin-induced ROS generation through Nrf2 activation in auditory cells (Kim et al., 2009)

Collectively, these potential clinical implications support further investigation and prioritization of this strategy in future translational and clinical trials