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According to Corrie et al., nanoparticles can improve efficacy and minimize side effects by extending the duration of drug circulation in the body and lowering the rate of drug clearance [188]

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Alternatively, oral capsules are available but have significantly lower bioavailability

While agar-based nanoparticle systems are still emerging in BBB research, several universal design principles apply: These parameters are critical in adapting established ligand systems to agar-based nanoparticle platforms

The best evidence for weight loss comes from a meta-analysis of 37 trials: a modest average reduction of about 1.2 kg (under 3 lbs), mostly in adults who are overweight