what is the use of glutathione in the body Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification 14 Glutathione Benefits for Your

While the role of NRF-2 has been proven in hepatic pathogenesis and it has been established as a potential therapeutic target, it is at present under worldwide researches.AbbreviationsAMPK-PGC-1 Activated protein kinase coactivator 1 alpha ARE antioxidant response element CLD chronic liver disease CYP cytochromes GST glutathione S transferase GSH glutathione HFD high fat diet HO-1 heme oxygenase 1 iNOS inducible form of nitric-oxid Synthase JAK2 janus kinasa 2 KEAP1 Kelch-like ECH associating protein-1 PTEN liver specific phosphatase and tensin homology UPRmt mitochondrial unfolded protein Response NAFLD nonalcoholic fatty liver disease NASH nonalcoholic steatohepatitis NRF-2 nuclear factor (erythroid-derived 2)-like 2 PGC-1a peroxisome proliferator-activated PTENLKO PTEN deletion mice RNS reactive nitrogen species ROS reactive oxygen species STAT5 signal transducer and activator of transcription 5 SIRT-1 sirtuine 1 SREBP-1 sterol regulatory element-binding protein-1 TRX thioredoxin-dependent enzymes UPR unfolded protein response Conflict of interest The authors have no conflicts of interest to declare whatsoever

J Pharm Pharmacol 76(8):10181027 Lu X et al (2021) MiR-27a-3p promotes non-small cell lung cancer through SLC7A11-mediated-ferroptosis

In ( f , i and j ) significance tested by two-sided Mann-Whitney

Biotin is an essential cofactor for keratin production, the structural protein of hair, skin, and nails

Toxins 13, 117

It is a natural and effective alternative to hydroquinone for inhibiting tyrosinase production