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This is based on typical values for bioavailability of 70% and total clearance of about 7 L/h (CL renal 4 L/h, CL nonrenal 3 L/h)

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The primary structure of IGF-I and Insulin-like Growth Factor-II (IGF-II) was discovered by Froesch and coworkers as a result of their persistent work to characterize the metabolic activity of NSILA (8,9)