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The usual intuition that a higher dose is at least a stronger version of the same thing is simply false here

Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma

B12 deficiency takes 13 years to show symptoms by then, nerve damage may be permanent

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If used at all, lower doses are recommended in the elderly to reduce the incidence of side effects and maintain age-dependent normal levels of IGF-1

Aphexda is the first approved therapeutic for BioLineRx, which also has offices in Waltham, Mass