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Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss (Hoepken et al., 2007)

In contrast, chronic co-exposure to arsenic and chromium causes additive nephrotoxicity in zebrafish through oxidative stress and impaired DNA repair

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Crit Rev Food Sci Nutr 58(5):741754