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Structure and Functions of mTORC1 The protein serine threonine kinase TOR (target of rapamycin) was initially identified in Saccharomyces cerevisiae as a target of the macrolide fungicide rapamycin and later, the mammalian counterpart was identified and named mammalian/mechanistic target of rapamycin (mTOR), also known as FRAP (FKBP12-rapamycin-associated protein), RAFT (rapamycin and FKB12 target), and RAPT1 (rapamycin target 1) ( mTORC1 is composed by the regulatory-associated protein of mTOR (Raptor), a scaffolding protein important for mTORC1 assembly, stability, substrate specificity and regulation (Figure 1)

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It is common practice, especially in children with drug-resistant epilepsy, to introduce KD in a hospital setting (64)

For instance, AuNPs could be functionalized with drugs or targeting molecules and used for targeted delivery of drugs or as contrast agents for imaging