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Next, we found that CXCL10 directly bound to IL18R1 to impair ovarian function through three pathways: inducing ovarian fibrosis through p-JNKp-JUN COL1A1, promoting primordial follicle overactivation through p-AKTp-FOXO3A, and increasing ovarian inflammation through p-P65 IFN

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Stifano G, Affandi AJ, Mathes AL, Rice LM, Nakerakanti S, Nazari B et al (2014) Chronic toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis

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Thorne puts all of their products through rigorous testing, and they partner with research organizations like Cleveland Clinic, Johns Hopkins, and the NIH