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The 1R ligand mediates the generation of new synapses and dendritic spines through the mitogen-activated protein kinase/extracellular regulated kinase and PI3K/AKT signaling pathways, thereby exerting neuroprotective effects [154]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Forman H.J., Zhang H., Rinna A