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The ACHIEVE-3 trial demonstrated that orforglipron was superior to oral semaglutide (Rybelsus) in both HbA1c reduction and weight loss in a head-to-head comparison, reducing HbA1c by approximately 2.2 percentage points versus 1.4 points with oral semaglutide, and producing 9.2% weight loss versus 5.3%

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Most clients begin with weekly injections for several weeks, then transition to maintenance doses every few weeks based on their health goals and response

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E.lvarez-ArellanoL.Corts-MendozaJ.et al (2019)

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