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[1] Various mechanisms for the hypopigmentary effect of glutathione have been proposed, with inhibition of tyrosinase being the most important [Box 2]

BMC Cancer

The hydroxyl radical (OH) is the most reactive ROS and can indiscriminately react with and damage almost all types of biomolecules, including lipids, proteins, and nucleic acids

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Gene set enrichment assay (GSEA) GSEA was conducted using the GSEA program provided by the Broad Institute ( All samples from the GSE39582 and GSE87211 datasets were first grouped according to KRAS mutation isotypes and then further subdivided based on HER2 or ELF3 expression levels (top 33%/bottom 33%) to define the phenotypes within the datasets