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Moreover, mice lacking both the Arx and the Pax4 genes display significant shrinkage of both - and -cell lineages and die neonatally because of lethal hyperglycemia 6

Among them, more genes had been observed be differentially expressed between bulb and stem (6494 genes) followed by bulb and flower comparison (6155 genes) than between pair of stem and flower tissues (4259 genes), which probably indicating, more genes are involved in the growth and development of bulbs

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Subsequent data collected on AD mice (3xTg-AD) support the concept that the oxidative damage of BVR-A is one of the earliest events observed during the development of BIR (410, 411)