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Subsequently, the increased histone lactylation facilitates the transcriptional activation of HIF-1 targets such as Bmp5, Trpc5, and Kit, thereby promoting PASMC proliferation and vascular remodeling

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Furthermore, the mRNA expression levels of apoptosis-related genes such as BAX and CASP3 (pro-apoptotic) were found to be lower in the Leo20 group than in the control group