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Experimental evidence points a multifactorial etiology, linking hyperglycemia with the activation of multiple cell phenomena such as polyol pathway, advanced glycation end-products formation, protein kinase C (PKC) and nuclear factor K signaling, among many others (Pacher, 2008

As such, we would like to stress the importance of performing both assessments in order to obtain the most complete information from every study

Fat-soluble vitamins A, D, E, and K build up in fat and liver tissue with repeated infusions because, unlike water-soluble vitamins, the body cannot simply excrete the excess

Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels