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Since the NO donor SNP induced LIP as chloroquine and bortezomib did, while the NO scavenger carboxy-PTIO abrogated the effects of the lysosome and proteasome inhibitors, we propose that chloroquine and bortezomib increased C/EBP- LIP either by preventing its degradation via lysosome and proteasome, or by eliciting a NO-dependent ER stress

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