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H.ChandV.et al

In PD, dysregulation of the Keap1/Nrf2 pathway has been reported, leading to impaired antioxidant defenses and increased vulnerability to oxidative stress (Mahapatra 2018)

., Jimnez-Fernndez, M., Cant-Lozano, D., Urrea-Garca, G

doi: 10.1007/s00259-021-05294-3 141 PretoriusEVenterCLaubscherGJKotzeMJOladejoSOWatsonLRet al

In most diseases, ROS appear to have a direct connection with inflammaging and cell senescence, and oxidative stress and inflammaging increase the aging-related phenotype, and induce and aggravate the inflammatory response, creating a chronic state of systemic inflammation (290297)