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Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits

Focused experiments conducted in rat striatum synaptosome preparations have reported that melatonin inhibits the excitatory response in a partially Ca 2+ -dependent manner in which the direct effect on membrane hyperpolarization promoted intracellular Ca 2+ influx reduction 94

This resistance is partially due to heightened and sustained activity of the transcription factor cAMP response element-binding protein (CREB), which prevents inhibition of the anti-apoptotic protein BCL-2 [22]

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Lab review (ferritin, transferrin saturation, hemoglobin, AST/ALT) is mandatory before treatment to ensure safety and proper dosing

Seneca, S