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Compared with native human GPx3 9 , less than 10% of the activity was retained when the rhGPx3 mutant catalyzed the reaction of H 2 O 2 to form the corresponding H 2 O, while 15.6% of the activity was retained using PLPC-OOH as the oxidizing substrate (Figure 2)

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Provider assessment of both genetic predisposition and current biomarker status can refine the rationale for supplementation and establish realistic expectations about benefit timeline and magnitude

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