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However, as specific pharmacological tools or inducible genetically engineered mouse models that allow manipulation of glutamatergic input are lacking, it is not known to what extent L-glu dysregulation contributes to disease progression in specific mouse models of different neurodegenerative diseases

95% CI 0.58-0.83) (75)

Electron microscopy was not applied in the study due to the long post-mortem period

Beneficial commensals generally promote immune tolerance and help reinforce the intestinal barrier, whereas an overgrowth of pathogenic bacteria or loss of key symbionts (dysbiosis) can provoke systemic inflammation [34]

Sperling RA, Parak WJ

Higher concentrations of kojic acid may result in faster results but with increased irritation, especially on sensitive skin