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Although it is mostly converted to nontoxic metabolites by sulfation and glucuronidation, a small amount of the drug is metabolized by cytochrome P450 enzymes (including subtype 2E1) into the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI)

Glutathione transporters are of utmost importance because they minimize the fluctuations in the GSH concentrations, as well as in the redox state of glutathione, in the different cellular compartments, while their synthesis, degradation and recycling act in a coordinated form

NSFC 82160484), Guizhou Province Science Plan Program [Qian Ke He Foundation-ZK (2022) general

Hydrogels and Implantable Systems Unlike drop-based nanoparticles, hydrogels and implants provide a depot effect for sustained release, reducing the burden of patient compliance

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