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Gao et al (43) reported that hydrogen peroxide-induced oxidative stress in tendon stem cells activates the cGAS-STING signaling pathway in parallel with mitochondrial damage, mitophagy dysregulation and ferroptosis-related molecular alterations, ultimately contributing to tendinopathy-associated pathological phenotypes

Despite the slight increase in PUFA-containing diacyl PEs, a-synuclein- or ACSL4 -depleted cells were resistant to ferroptosis, suggesting that ether lipids are more critical than diacyl lipids to ferroptosis, at least in this cellular context 138

For example, single-cell sequencing has revealed that neurons upregulate glucose transporter GLUT3 and hexokinase 2 gene expression under oxidative stress, while live-cell imaging directly visualizes mitochondrial reorganization and glycolytic enzyme relocalization during surges in energy demand

In epilepsy, astrocytes adopt a reactive morphology (Heinemann et al., 2000

In conclusion, both EMPA and TRF, when used separately, attenuated several adverse cardiovascular effects of Dox in animal models, highlighting their potential to prevent cardiotoxicity in a context-dependent manner

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