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Autoimmune ablation of the inhibitory motor innervation of the lower esophageal sphincter underlies achalasia, megaesophagus, and disordered swallowing

(2020) 52:475486.e5

Insulin resistance also reduces free carnitine levels [28, 29], further impairing mitochondrial energy production

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In addition to its catalytic activity, aldolase has been reported to have several moonlighting functions such as WASP and actin binding 34,35,36 , regulation of endocytosis via SNX9 37 and modulation of AMPK signalling 38,39