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Native MGF Biology Native MGF is a 49-52 amino acid splice variant of IGF-1 (specifically the IGF-1Ec isoform) that differs from systemic liver-derived IGF-1 in its C-terminal E domain sequence, created through alternative splicing of the IGF-1 gene in response to mechanical signals in muscle tissue

Beyond the somatopause: growth hormone deficiency in adults over the age of 60 years

Both peptides bind to the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a) on pituitary somatotropes, triggering pulsatile GH release

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The high GH levels, together with the often severe IGF-1 deficiency, will lead to a severe catabolic state, including significant lipolysis and proteolysis, comparable to extended fasting during a hunger strike, for instance [26]