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Single nucleotide variations in the C13orf31 gene , resulting in amino acid changes in p.C284R and p.I254V in a protein of unidentified function, play a role in the development of systemic juvenile idiopathic arthritis and are associated with heightened susceptibility to leprosy and CD (66).This suggests that individuals with IBD may have an inherent vulnerability to mitochondrial dysfunction, particularly influenced by the gut environment

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Rapid acceleration/deceleration induces shearing forces on the axons which cause stretching and tearing damage

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Mitochondrial regulation of the tumor microenvironment Mitochondria are central to the dynamic interplay between cancer cells and the various immune populations that infiltrate the TME