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PIG3 knockdown significantly inhibited the migration and invasion ability of NSCLC cells and decreased paxillin, phospho-focal adhesion kinase (FAK), and phospho-Src kinase expression, while its overexpression resulted in the opposite effects

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The increased levels of lipid peroxide and ROS in FRDA neurons and the decrease in GSH content increase the sensitivity to oxidants, suggesting that FRDA may be closely related to ferroptosis 69