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In epilepsy models, pro-inflammatory cytokines downregulate this pathway via phosphatase and tensin homolog (PTEN)-mediated suppression, thereby reducing neuronal survival and synaptic efficacy

Hydroperoxide formed during the reaction with vitamin E and peroxyl radicals is removed because it disturbs cell membrane and its function

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PDGFR expression is typically downregulated as OPCs differentiate into mature oligodendrocytes

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