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Another ruthenium compound, [Ru(6-anethole)(en)X]PF6I, also induced significant overexpression of pro-apoptotic genes as caspase-3, PUMA, and DIABLO in AGS cells, supporting a mechanism of apoptosis similar to that seen with other ruthenium compounds [98]

Clinically, modulating CHAC1 in combination with chemotherapy, radiotherapy, or immunotherapy could enhance treatment efficacy and overcome resistance in cancer patients