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Hepatology 30:613 Venneman NG, Besselink MG, Keulemans YC, Vanberge-Henegouwen GP, Boermeester MA, Broeders IA, Go PM, van Erpecum KJ (2006) Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy

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Environmental stressors like air pollution, sunlight, and even the mental stress of a workday can increase free radical production