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Comparison CompoundClassPathway / targetResearch focusFormat 5-Amino-1MQSmall moleculeNNMT inhibitionNAD / SAM metabolismVial 5-Amino-1MQ CapsulesSmall moleculeNNMT inhibitionNAD / SAM metabolismCapsules SLU-PP-332Small moleculePan-ERR agonismMitochondrial gene expressionVial SLU-PP-332 CapsulesSmall moleculePan-ERR agonismMitochondrial gene expressionCapsules Tesofensine CapsulesSmall moleculeMonoamine reuptakeCNS / monoaminergic signallingCapsules Enclomiphene CapsulesSmall moleculeEstrogen receptor (SERM)HPG-axis signallingCapsules AICARSmall moleculeAMPK activationCellular energy sensingVial AOD-9604Peptide fragmenthGH fragment (176-191) signallingLipolytic-pathway signallingVial AOD-9604 CapsulesPeptide fragmenthGH fragment (176-191) signallingLipolytic-pathway signallingCapsules GLP-3 (Reta)PeptideIncretin receptorMetabolic signalling researchVial Every compound in this category is supplied as Research Use Only material with: Peer-reviewed literature and mechanism background underpinning this category are maintained in the linked research articles below

Proc Natl Acad Sci USA 116:1393713942 Acknowledgements This research was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (BB/V003577/1) and a BBSRC Flexible Talent Mobility Accounts grant to facilitate collaboration with the University of Georgia (BB/X01763X/1)

of lipid droplets and histo- logical lesion, #Hmgcr and miR-33a Groups 5, 6: #Srebf2 Groups 4, 5: "Cyp7a1 Lee et al, 2020 34 Morus alba fer- mented extract M: Male C57BL/6N mice A/W: 8 wk 1

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Blocking of amino acid uptake by pharmacologically inhibiting relevant transporters also disrupts tumorous metabolic addictions (Lukey et al., 2017