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Los COP se excretan principalmente mediante conjugacin con GSH y este mecanismo es extremadamente importante para el estado de salud, ya que la exposicin a los COP se ha asociado con diabetes, enfermedades cardiovasculares y muchas otras enfermedades crnicas

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Secondly, such deficiency seems to be intimately related to the onset of MetS and establishment of vascular derangements leading to atherosclerosis and finally playing a definitive part in cerebrovascular and myocardial accidents, where IGF1 deficiency seems to render these organs vulnerable to oxidative and apoptotic/necrotic damage