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Novel biomarkers based on proteomics (231, 232), metabolomics (233, 234) and transcriptomics (235, 236) have emerged, contributing to disease assessment, treatment monitoring, and prognosis

In Parkinsons disease, for example, differences between normative and patient-specific brain connectivity from easier to define gray matter DBS targets (subthalamic nucleus, globus pallidus) may be smaller [59] than in many psychiatric disorders that may need more individualization given that targets are located at critical junctions of white matter networks (internal capsule, subcallosal cingulate-SCC) that are complex and variable [60, 61]

139 PalmieriL.ArrigoniR.BlancoE.CarrariF.ZanorM

The mechanisms behind clinical resistance to proteasomal inhibitors remain elusive

Although we could not measure formaldehyde-derived DNA adducts in the Aldh2 / /Adh5 / organs in this study, we expect that tissues in Aldh2 / /Adh5 / mice may show a marked increase in formaldehyde-derived DNA adducts compared to single Aldh2 / and Adh5 / mice as well as wild-type mice

De Vincenzo R, Ferlini C, Distefano M, Gaggini C, Riva A, Bombardelli E, Morazzoni P, Valenti P, Belluti F, Ranelletti FO, Mancuso S, Scambia G (2000) In vitro evaluation of newly developed chalcone analogues in human cancer cells