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Brady PC and Barbieri R

And they know it

As with other highly active corticosteroids, therapy should be discontinued when control has been achieved

After all, this is how doctors have had to "practice medicine" for centuries - it's only recently that we have discovered the genetics data in detail, but science still doesn't yet have a broad knowledge about how to use it all (it's a pretty massive learning curve that the research world has been working to better understand)