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Oxidative stress Oxidative stress is a pivotal mechanism behind ECD [99, 100], consisting of an imbalance of the redox state due to reactive oxygen species (ROS) overproduction, antioxidant systems depletion, or both

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Additionally, studies showed that various microbiota metabolites, such as short-chain fatty acids (SCFAs), tryptophan metabolites, and amine derivatives, including trimethylamine N-oxide (TMAO), play an important regulatory role in autoimmune diseases (Stec et al., 2023)

Finally, we discuss how individual variation arises and its consequences for one-carbon and glutathione metabolism

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Key functions of glutathione Fights oxidative stress: Glutathione helps neutralise harmful free radicals by donating a hydrogen atom to them, reducing cellular damage and inflammation