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We identified the three main chondrocyte differentiation stages using previously described marker genes (Extended Data Fig

However, fatigue can have many causes, including anaemia, thyroid problems, infections, sleep disorders, mental health issues, or heart and lung diseases

,,Carmona-CuencaI,RonceroC,SanchoP,CajaL,FaustoNFernandezMet al.Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity.2008;49(6):965976

Subsequently, the skin sections with the scratching areas and adjacent regions were preserved in 4% paraformaldehyde for 24 h and then embedded in the paraffin wax

Nonetheless, environmental stressors like UV radiation, heat, or air pollution can cause a surge in ROS levels, potentially leading to significant cellular damage 34

These temperature-sensitive peptide medicationsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)require specific storage conditions to maintain therapeutic effectiveness