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Apart from telaprevir and boceprevir, other NS3/4A protease inhibitors have been developed to overcome the current limitations of first-generation drugs, with regard to the pharmacokinetic profile, barrier to resistance, adverse events and activity among other genotypes.[75] Simeprevir (TMC-435), the next line protease inhibitor, demonstrates good tolerability even with the infrequent mild and asymptomatic hyperbilirubinaemia (reversible at the end of the therapy).[76, 77] It is effective against HCV-1, but also against HCV-2, HCV-5 and HCV-6

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Feb 3 2022;128(12):1-12

In human HCC cell lines, knockdown of HMGCS2 increases tumor growth and cell migration, while HMGCS2 overexpression decreases cell proliferation and increases apoptosis (Wang et al., 2019b

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