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R., Solaymani-Dodaran, M

Keywords Reactive nitrogen species, reactive oxygen species, endoplasmic reticulum stress, unfolded protein response, drug-induced liver injury Introduction Drug-induced liver injury (DILI) plays an essential role both in the clinic and in drug development [1]

[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Nunn AVW, Guy GW, Botchway SW, Bell JD

2020;12:15 Salardini E, ODell RS, Tchorz E, Nabulsi NB, Huang Y, Carson RE, et al

Other mechanisms that regulate the intracellular iron abundance, such as the exportation of iron via various multivesicular bodies and exosomes carrying ferroportin or prominin2-mediated ferritin, can also affect the cellular sensitivity to ferroptosis, as they deplete the cellular iron and accelerate the lipid peroxidation (53) ( Figure 1 )

Asgharpour A, Cazanave SC, Pacana T, Seneshaw M, Vincent R, Banini BA, Kumar DP, Daita K, Min HK, Mirshahi F, Bedossa P, Sun X, Hoshida Y, Koduru SV, Contaifer D Jr, Warncke UO, Wijesinghe DS, Sanyal AJ (2016) A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer