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10.1016/j.mmcr.2015.01.003 [DOI] [PMC free article] [PubMed] [Google Scholar] 163.Payne CL, Dark MJ, Conway JA, Farina LL

These findings support the hypothesis that TXNIP overexpression inhibits metformin-induced upregulation of GLUT1 expression in enterocytes, thereby influencing glucose uptake

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Figure 3 In response to this unmet clinical need, the field has shifted toward developing neuroprotective therapies that directly preserve RGCs and support the health of the optic nerve as can be seen in Figure 3B

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This is significant, as there have been a number of animal studies confirming the effect of GlyNAC before, but this is the first work where the effectiveness of GlyNAC in humans has been impressively demonstrated