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It is possible that changes in trigonelline and adenosine, but not nicotinamide level, were detected due to their higher bioavailability and stability in plasma

Moreover, Nguyen et al

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Experimental vascular studies using isolated rat aorta preparations reported that BPC-157 modulated vasomotor tone and increased nitric oxide generation through activation of the SrcCaveolin-1endothelial nitric oxide synthase (eNOS) signaling pathway [3]