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Inflammatory bowel disease induces inflammatory and pre-neoplastic changes in the prostate

Due to their high rate constant and high abundance, Prx are thought to be responsible for scavenging nanomolar concentrations of H 2 O 2 associated with redox signaling, while Gpx are likely important at higher intracellular concentrations, buffering high ROS levels to avoid cell damage and stress signaling response (Sena and Chandel, 2012)

Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment

Use of Depakote ER during pregnancy can cause congenital malformations including neural tube defects